Bullous Pemphigoid – Overview
Bullous pemphigoid is a rare autoimmune skin condition that causes large, fluid-filled blisters to form on areas of the skin that often flex — such as the abdomen, arms, legs, and groin. This is most commonly affects older adults and can range from mild to severely disabling depending on the extent and location of the blisters.
This chronic condition occurs when the body’s immune system mistakenly attacks the basement membrane — the thin layer of tissue that anchors the outer layer of skin (epidermis) to the underlying dermis. As a result, inflammation develops and the skin layers separate, forming blisters.
The blisters are usually firm, dome-shaped, and filled with clear fluid. They do not rupture easily and are often very itchy. In some cases, redness and welts appear before blistering begins. The condition typically lasts for months or even years, with periods of flare-ups and remission.
Bullous pemphigoid
While not contagious or cancerous, this condition can significantly affect a person’s quality of life. Scratching and broken blisters may lead to infections, scarring, or skin thickening.
Treatment usually involves corticosteroids and immunosuppressants to calm the immune response, along with topical ointments to manage itching and inflammation. With proper care, most individuals can control the disease and reduce symptoms over time.
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