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Treatment of Complex Regional Pain Syndrome

Various blister packs of colourful medication tablets and capsule

A variety of medications often used in the treatment of complex regional pain syndrome (CRPS), including pain relievers and nerve-blocking drugs

Treatment of Complex Regional Pain Syndrome

Treatment of complex regional pain syndrome aims to reduce pain, restore function, and improve the patient’s quality of life. Since no single treatment is universally effective, management of CRPS is often multidisciplinary, involving a combination of medications, physical therapy, psychological support, and sometimes interventional procedures.

Medications

Various medications help control CRPS symptoms:

Pain relievers: NSAIDs like ibuprofen for inflammation and mild pain

Neuropathic pain medications: Amitriptyline, gabapentin, or pregabalin

Corticosteroids: Short-term use to reduce inflammation and swelling

Bisphosphonates: May help with bone pain and density loss

Topical creams: Such as lidocaine or capsaicin for localised relief

Opioids are usually avoided due to dependence risks and poor long-term effectiveness.

Physical and Occupational Therapy

Maintaining movement is crucial. A physiotherapist can help with:

Graded exercises to restore strength and flexibility

Desensitisation techniques

Joint mobilisation and muscle stretching
Occupational therapy focuses on adapting daily activities and improving function.

Psychological Support

Chronic pain can lead to depression, anxiety, and fear of movement. Cognitive behavioural therapy (CBT) and counselling help patients develop coping strategies and maintain emotional well-being.

Interventional Treatments | Treatment of Complex Regional Pain Syndrome

For severe cases, interventional options may be explored:

Nerve blocks: Temporary relief through local anaesthetic injections

Spinal cord stimulation: An implanted device modulates pain signals

Sympathectomy: A surgical option, now rarely used, to cut sympathetic nerves

Mirror therapy, graded motor imagery, and virtual reality therapies are emerging treatments aimed at retraining the brain’s pain processing.

In summary, treatment must be personalised and proactive. Early, multidisciplinary intervention offers the best chance for symptom control and functional recovery.

[Next: Complications and Recovery from Complex Regional Pain Syndrome →]

Dr Francois Steyn Anaesthesiologist Nelspruit
Causes of Complex Regional Pain Syndrome
Diagnosis of Complex Regional Pain Syndrome
Complex Regional Pain Syndrome

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