Brugada Syndrome – Overview Brugada syndrome is a rare but serious genetic heart condition that affects the way electrical signals pass through the heart. This syndrome can cause abnormal heart rhythms (arrhythmias), which may lead to fainting, seizures, or sudden cardiac death — particularly in young adults and otherwise healthy individuals. This condition often goes unnoticed because people may not show any symptoms until a significant event occurs. In many cases, it’s only diagnosed after an abnormal electrocardiogram (ECG) or following an unexplained fainting episode or cardiac arrest. The condition is more common in men and often appears between the ages of 30 and 40. This syndrome affects the sodium channels in the heart, which play a key role in the electrical system that controls heartbeat. When these channels don’t function properly, it can disrupt the heart’s rhythm and cause it to beat dangerously fast or irregularly, particularly during rest or sleep. Brugada Syndrome Because this syndrome can result in sudden death without prior warning, early detection is critical. Diagnosis is based on a characteristic ECG pattern and sometimes confirmed by genetic testing. Once identified, treatment options include medication, lifestyle changes, and in high-risk cases, the placement of an implantable cardioverter-defibrillator (ICD). While there is currently no cure, people with Brugada syndrome can lead full lives with appropriate monitoring and medical care. [Next: Causes of Brugada Syndrome →]