Causes of Carpal Tunnel Syndrome Causes of carpal tunnel syndrome include repetitive wrist movements, underlying medical conditions, and anatomical factors that put pressure on the median nerve. The most common causes involve repetitive strain, wrist injuries, and chronic inflammation. 1. Repetitive Strain Jobs or hobbies that require frequent wrist flexing or hand movements — such as typing, assembly line work, sewing, or playing musical instruments — can strain the wrist and inflame surrounding tissues. Over time, this leads to swelling within the carpal tunnel and nerve compression. 2. Medical Conditions Certain health issues increase the risk of developing carpal tunnel: 3. Trauma or Injury Wrist fractures, sprains, or dislocations can alter the shape of the carpal tunnel or create scar tissue, compressing the nerve. 4. Hereditary Factors Causes of Carpal Tunnel Syndrome Some people are born with a narrower carpal tunnel, which increases their vulnerability. Family history is often a contributing factor. Other causes include: Identifying the causes helps guide prevention strategies — such as ergonomic workspaces, regular stretching, and early treatment for related health conditions. [Next: Symptoms of Carpal Tunnel Syndrome →]