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Causes of Food Allergy

The eight most common food allergens in black icon format

The “Big 8” food allergens known to cause allergic reactions in sensitive individuals

Causes of Food Allergy

The causes of food allergy are related to the immune system mistakenly identifying certain food proteins as threats. Food allergy can develop at any age, but it most commonly begins in infancy or early childhood. The reasons why some people develop food allergies while others don’t are not fully understood, but a combination of genetics, environment, and immune system development play key roles.

Immune System Reaction

The immune system produces IgE antibodies in response to a food protein

On subsequent exposure, these antibodies trigger the release of histamine and other chemicals, leading to allergic symptoms

This reaction happens quickly—within seconds to minutes of eating the allergen

Genetic and Family Factors

Food allergies often run in families

If one parent has an allergy, the child has an increased risk; if both do, the risk is even higher

Children with eczema, hay fever, or asthma are more likely to develop food allergies

Early Life Exposure

Delayed introduction of allergenic foods in infants was once common but may increase risk

Recent guidelines recommend early, gradual introduction (e.g., of peanut butter) under medical guidance in high-risk infants

Breastfeeding and gut health may influence immune tolerance, although the evidence is still evolving

Environmental Factors

Western lifestyles may contribute to rising allergy rates due to reduced exposure to microbes

The “hygiene hypothesis” suggests a lack of exposure to everyday germs may skew the immune system towards allergic responses

Pollution and changes in the food supply may also influence sensitisation

Other Risk Factors

Severe eczema in infants is a strong predictor of future food allergies

Existing allergies (e.g., to dust mites or pollen) may increase sensitivity to certain plant-based foods due to cross-reactivity

Some children with milk or egg allergies are more likely to develop multiple food allergies over time

Causes of Food Allergy

Understanding the causes of food allergy helps guide prevention efforts, early diagnosis, and research into better treatments. While some risk factors can’t be changed, others—like early food exposure and dietary diversity—are now being studied for their protective potential.

[Next: Symptoms of Food Allergy →]

Dr Ria J Bester Radiologist Bellville
Understanding Eating Disorders
Chest and Allergy Centre Cape Town City Centre
Causes of Eating Disorders
Royal Paediatrics and Allergy Claremont

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