Complications of Angelman Syndrome

Complications of Angelman Syndrome

Although Angelman Syndrome is not progressive, individuals may face lifelong challenges that affect mobility, communication, learning, and health. Early support helps reduce complications of Angelman syndrome and improve independence.

Common Long-Term Complications

1. Seizures
   • Occur in about 80–90% of children with Angelman Syndrome
   • Usually appear between ages 1–3 but often become less severe with age
2. Speech and Communication Delays
   • Most individuals are nonverbal or use minimal words
   • AAC devices and structured routines are essential
3. Mobility and Balance Issues
   • Ataxia (impaired coordination) makes walking and movement difficult
   • Many children walk later than peers and may have an awkward gait
4. Feeding Difficulties
   • Problems with chewing, swallowing, or drooling are common in infancy and early childhood
5. Sleep Disturbances
   • Insomnia, frequent waking, and short sleep cycles are persistent issues
6. Scoliosis and Orthopaedic Problems
   • Curvature of the spine and joint stiffness may develop, particularly in non-mobile individuals
7. Behavioural Challenges
   • Hyperactivity, short attention span, and frequent laughing may affect learning
   • These traits are part of the syndrome’s neurological profile and not behavioural disorders

Emotional and Social Impact

• Families often experience emotional, financial, and physical stress.
• Support groups, community organisations, and professional counselling can make a major difference.
• Many children are social, affectionate, and cheerful, which brings joy to families despite the challenges.

Life Expectancy

• Most people with Angelman Syndrome live into adulthood, often into their 60s or beyond.
• Ongoing therapy, good nutrition, and seizure management contribute to longer, healthier lives.

With the right care, people with Angelman Syndrome can participate in family, community, and even assisted work environments, bringing positivity to those around them.

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Causes and Genetics of Angelman Syndrom

Angelman Syndrome Overview

Diagnosis of Angelman Syndrome

Treatment for Angelman Syndrome