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Diagnosis of Chickenpox

Doctor examining red rash on a male patient's back for chickenpox diagnosis

A healthcare professional uses a dermatoscope to examine a blistering rash during a chickenpox assessment.

Diagnosis of Chickenpox

Diagnosis of chickenpox is often clinical — based on the characteristic rash and symptoms — but additional tests may be used in uncertain or severe cases. Accurate diagnosis of chickenpox ensures appropriate care and helps prevent complications, especially in vulnerable patients.

1. Clinical Examination

Doctors usually diagnose chickenpox by:

  • Examining the rash’s appearance and distribution
  • Taking a history of recent exposure or known outbreaks
  • Assessing fever, fatigue, and other flu-like symptoms

The presence of lesions in different stages (red spots, blisters, scabs) is highly suggestive of chickenpox.

2. Patient History | Diagnosis of Chickenpox

A thorough history is essential, especially to determine:

  • Prior infection or vaccination status
  • Recent contact with someone who had chickenpox or shingles
  • Travel to areas with known outbreaks

In vaccinated individuals, breakthrough chickenpox can be harder to recognise due to milder symptoms.

3. Laboratory Tests (if needed)

Although usually not necessary, the following tests may be used in complex or hospitalised cases:

  • Polymerase chain reaction (PCR): Detects varicella DNA in fluid from a blister or blood
  • Direct fluorescent antibody test: Identifies virus proteins in lesion samples
  • Serology (antibody tests): Determines immunity or confirms past exposure

These tests are especially useful in adults, pregnant women, or immunocompromised individuals where chickenpox could be mistaken for other illnesses.

4. Differential Diagnosis | Diagnosis of Chickenpox

Other conditions that may resemble chickenpox include:

  • Hand, foot and mouth disease
  • Insect bites
  • Drug rashes
  • Eczema herpeticum
  • Scabies (in rare cases)

An experienced healthcare provider can usually differentiate these based on history and clinical signs.

A confident diagnosis of chickenpox helps avoid unnecessary medications, ensures timely treatment, and supports effective infection control in households and healthcare settings.

[Next: Treatment of Chickenpox →]

Complications and Recovery from Chickenpox
Symptoms of Chickenpox
Chickenpox
Causes of Chickenpox

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