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Symptoms of Endocarditis

Woman clutching chest in discomfort, indicating possible symptoms of endocarditis.

A young woman holding her chest, possibly experiencing discomfort or pain—an early symptom of endocarditis, which often mimics heart-related conditions.

Symptoms of Endocarditis

The symptoms of endocarditis can vary widely and often resemble other illnesses, making the condition difficult to diagnose in its early stages. Because endocarditis affects the heart’s inner lining and valves, symptoms arise from infection, inflammation, and impaired blood flow. Prompt recognition is essential to avoid serious complications.

General Symptoms

These are often the first signs:

Fever and chills, especially recurring or persistent

Fatigue and weakness

Muscle and joint pain

Night sweats

Loss of appetite and weight loss

These non-specific symptoms may develop slowly in subacute endocarditis or rapidly in acute cases. Patients may dismiss them as flu or a common infection.

Heart-Related Symptoms

As the infection progresses, patients may notice:

Shortness of breath

Swelling in the legs, feet, or abdomen (due to heart failure)

Chest pain, particularly if the infection affects blood flow

Heart murmurs, which may be new or changing

Doctors often detect a murmur using a stethoscope, especially in people with valve infections.

Specific Signs of Endocarditis

More advanced or classic signs include:

Petechiae – small red or purple spots on the skin or inside the mouth

Osler’s nodes – painful red bumps on fingers or toes

Janeway lesions – painless spots on palms or soles

Roth spots – small retinal haemorrhages seen in eye exams

Splinter haemorrhages – thin, red lines under the nails

These signs appear due to small clots or pieces of infected material travelling from the heart to other parts of the body.

Symptoms of Endocarditis

Complications and Red Flags

In advanced cases, symptoms may include:

Stroke symptoms (sudden weakness, confusion, speech difficulty)

Kidney pain or blood in the urine

Persistent coughing or fluid in the lungs

In South Africa, people living with HIV or in rural areas may present later in the disease course, increasing the risk of complications.

Recognising the symptoms of endocarditis early can be life-saving. Anyone with heart problems, a history of valve disease, or unexplained fever and fatigue should see a doctor without delay.

[Next: Diagnosis of Endocarditis→]

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