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Causes of Compartment Syndrome

Illustration of a woman holding her lower leg in pain with injury symbols

Illustrated depiction of lower leg injury as a common cause of compartment syndrome in active individuals

Causes of Compartment Syndrome

Causes of compartment syndrome differ depending on whether the condition is acute or chronic. In both types, however, the underlying mechanism is an increase in pressure within a closed muscle compartment that compromises blood flow and tissue function. Compartment syndrome often arises from injury, but it can also occur without direct trauma in specific scenarios.

Acute Compartment Syndrome | Causes of Compartment Syndrome

Acute compartment syndrome usually results from trauma and is considered a surgical emergency. The most common causes include:

Fractures: Particularly of the tibia or forearm, these account for a large percentage of acute cases.

Crush injuries: Accidents involving heavy machinery or falls can cause internal bleeding and swelling.

Severe bruising or haemorrhage: Bleeding inside the compartment from torn blood vessels increases pressure.

Burns: The skin acts as a rigid boundary; swelling underneath it can cause rapid pressure build-up.

Constrictive bandages or casts: Tight dressings can increase compartment pressure if not applied correctly.

Reperfusion injury: After restoring blood flow to a limb that was previously deprived of oxygen, sudden swelling may occur, triggering the condition.

Chronic (Exertional) Compartment Syndrome

This form usually affects athletes and occurs during repetitive exercise. Triggers include:

Running or cycling: Continuous use of lower limb muscles causes swelling during activity.

Overuse injuries: High-intensity or prolonged physical activity causes muscle expansion in compartments with limited capacity.

Improper footwear or biomechanics: These may alter muscle workload and aggravate symptoms.

Chronic compartment syndrome often presents with recurring pain, tightness, and muscle weakness during exercise, which subsides with rest.

Other Contributing Factors | Causes of Compartment Syndrome

Certain medical conditions and external factors can also contribute to developing compartment syndrome:

Blood clotting disorders

Use of anticoagulant medications

High-pressure intravenous infusions or injections

Recognising the causes of compartment syndrome helps clinicians assess at-risk individuals more effectively. Whether caused by trauma or repetitive activity, prompt diagnosis and intervention are key to preventing irreversible tissue damage.

[Next: Symptoms of Compartment Syndrome →]

Complications and Recovery from Compartment Syndrome
Compartment Syndrome
Diagnosis of Compartment Syndrome
Treatment of Compartment Syndrome

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