Epidermolysis Bullosa
Epidermolysis bullosa is a group of rare, inherited skin disorders that cause the skin to become extremely fragile. Even the slightest friction or trauma can lead to painful blisters, open wounds, and skin infections. Epidermolysis bullosa often begins at birth or in early infancy and can range from mild to life-threatening.
The condition occurs because the skin layers do not bind together properly. In healthy skin, the outer layer (epidermis) is firmly attached to the layer beneath (dermis). In people with this condition, the anchoring proteins or collagen fibres that hold these layers together are missing or faulty. This results in skin that tears or blisters with minimal pressure or rubbing.
There are several types of epidermolysis bullosa (EB), with varying severity:
EB simplex – the most common and usually mild, affecting mainly the hands and feet
Junctional EB – more severe, often beginning at birth, and may involve internal organs
Dystrophic EB – causes scarring and can lead to long-term disability
Kindler syndrome – a rare form with features of all other types
Epidermolysis Bullosa
In South Africa, access to diagnosis and specialist care for EB can be limited, especially in rural areas. As a result, many families struggle with wound management, nutrition, and mobility challenges without adequate medical guidance.
Though EB is rare, the impact on quality of life is immense. Children often live with daily pain, limited mobility, and a high risk of infections. With early diagnosis, specialised wound care, and supportive therapies, many individuals can live longer, more comfortable lives.
Understanding epidermolysis bullosa is the first step toward offering proper care and reducing unnecessary suffering.
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Causes and Types of Blisters
