Treatment of Corticobasal Degeneration
Treatment of corticobasal degeneration focuses on managing symptoms, as there is currently no cure or disease-modifying therapy. A multidisciplinary approach involving neurologists, physiotherapists, occupational therapists, and speech-language pathologists is essential to address the wide range of issues caused by corticobasal degeneration.
Medication
Although medications cannot stop disease progression, they can help relieve some of the symptoms:
Levodopa or dopamine agonists may offer limited relief from stiffness or tremor but are usually less effective than in Parkinson’s disease.
Muscle relaxants or botulinum toxin injections may reduce dystonia or painful muscle contractions.
Antidepressants or anxiolytics can be prescribed to manage emotional or behavioural symptoms such as depression or anxiety.
Antiepileptic medications are sometimes used to reduce limb jerking or myoclonus.
Physical and Occupational Therapy
These therapies play a critical role in maintaining mobility and independence:
Physiotherapy helps improve balance, gait, and flexibility
Occupational therapy focuses on adapting daily activities and using assistive devices to reduce strain and enhance function
Hand therapy may help with fine motor tasks and reduce rigidity in the hands
Speech and Language Therapy
As speech and swallowing become affected, speech therapists assist with:
Voice exercises to slow deterioration
Alternative communication tools for severe cases
Swallowing strategies or modifications to prevent choking
Nutritional Support | Treatment of Corticobasal Degeneration
Dieticians may recommend food texture changes and nutritional supplements to prevent weight loss or dehydration. In advanced cases, a feeding tube may be considered.
Supportive Equipment
Walking aids, braces, or adapted utensils improve daily functioning
Home modifications such as grab bars or stair lifts may enhance safety
Palliative and Emotional Support | Treatment of Corticobasal Degeneration
Psychological counselling, social support, and palliative care planning help improve quality of life for both patients and carers.
In summary, treatment of corticobasal degeneration is symptom-driven and requires a holistic care team. Though the disease cannot be reversed, consistent therapy and support can prolong independence and comfort.
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